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Figure 1 | Molecular Pain

Figure 1

From: Pre-injury administration of morphine prevents development of neuropathic hyperalgesia through activation of descending monoaminergic mechanisms in the spinal cord in mice

Figure 1

Pre-injury morphine-induced analgesia in partial sciatic nerve injury model mice. A-F: Pre-injury single administration of s.c. (1, 3, 10 mg/kg), and i.c.v. (0.3, 1, 3 nmol), but not i.t. (3, 10, 30 nmol), morphine prevented the development of thermal (A-C) and mechanical hyperalgesia (D-F) in the nerve-injured mice at 7 days following injury compared with vehicle pretreatment (Pre-injury Morph 0). Post-injury injection of 10 mg/kg s.c. morphine (30 min after surgery) failed to prevent the development of thermal or mechanical hyperalgesia. 'Sham' indicates thermal paw withdrawal latencies or mechanical paw withdrawal thresholds in control sham-operated mice. 'Morph' is morphine. Each data represents mean ± SE from 6–7 mice; *p < 0.05 compared with the group receiving vehicle as pretreatment.

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Molecular Pain

ISSN: 1744-8069

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