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Figure 3 | Molecular Pain

Figure 3

From: Propofol suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABAA receptor chloride channels

Figure 3

Propofol decreases corticothalamic-evoked spike firing in VB neurons. A: action potentials were evoked by corticothalamic (CT) stimulation in a VB neuron under control conditions. B: bath-application of propofol (0.6 μM) suppressed spike generation, and this suppression could be blocked by 10 μM bicuculline (C). Propofol was applied 20 min before the trace in (B) was recorded. D: bar graph indicates that propofol suppressed successful synaptic transmission (% suppression) at CT synapses in VB in a concentration-dependent manner. *, P < 0.05, one-way ANOVA, vs. control, n = 15.

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Molecular Pain

ISSN: 1744-8069

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