Figure 1

Kinetics of capsaicin-activated currents in HEK293 cells stably expressing rat TRPV1 channels. Application of increasing concentrations of capsaicin to cells voltage clamped at -60 mV result in progressively larger inward currents with faster activation rates and slower deactivation rates. (A) Representative current traces. (B) Plot of average activation and deactivation rates as a function of capsaicin concentration. Data are the mean ± SEM.