Figure 4
From: Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins
Interaction between TRPV1 and EP1 receptors in a behavioral level. (A) PGE2-induced thermal hyperalgesia in wild type mice with (▴, n = 6) or without (○, n = 6) pretreatment (ONO-8713, 500 pmol/ 20 μL), or in EP1 -/- mice (•, n = 6). * p < 0.05 vs. wild type mice. (B) 10% Mustard oil-induced thermal hyperalgesia in wild type mice (○, n = 12), TRPV1-/- mice (▲, n = 6) or EP1 -/- mice (•, n = 6). * p < 0.05, ** p < 0.01 vs. wild type mice.