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Figure 5 | Molecular Pain

Figure 5

From: Increased glutamate synaptic transmission in the nucleus raphe magnus neurons from morphine-tolerant rats

Figure 5

MDL12330a reverses the chronic morphine effect on glutamate EPSCs in tolerant secondary cells. A, Representative EPSC pairs in tolerant cells without (tolerant) and after treatment with the adenylyl cyclase (AC) inhibitor MDL12330a (MDL, 100 μM). B, Normalized EPSC pairs from A. C, Group data of the MDL effect on the PPR in cells from morphine-tolerant (n = 16) and saline control rats (n = 5). D,E, Representative current traces (D) and a plot of mEPSC frequency distribution (E) in a tolerant cell before and during application of MDL (100 μM). F, Group data of the MDL effect on mEPSC frequency in tolerant and saline control cells (n = 5 in each group).

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Molecular Pain

ISSN: 1744-8069

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