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Figure 4 | Molecular Pain

Figure 4

From: The chemerin receptor 23 agonist, chemerin, attenuates monosynaptic C-fibre input to lamina I neurokinin 1 receptor expressing rat spinal cord neurons in inflammatory pain

Figure 4

Monosynaptic C-fibre input to lamina I NK1R+ neurons. A. and B. Characterisation of primary afferent input to lamina I NK1R+ neurons receiving monosynaptic C-fibre only and monosynaptic C-fibre with polysynaptic A δ-fibre input, respectively. Left traces show examples of ESPCs evoked by dorsal root stimulation at A β- (20 μ A), A δ- (100 μ A) and C-fibre (500 μ A) intensities, at low frequency (0.05 Hz). Each trace is an average of 3 traces. Right traces show examples of EPSCs evoked using higher-frequency stimulation (20 μ A/20 Hz; 100 μ A/2 Hz; 500 μ A/1 Hz). Each trace comprises 20 superimposed traces.

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Molecular Pain

ISSN: 1744-8069

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