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Figure 5 | Molecular Pain

Figure 5

From: A simplified up-down method (SUDO) for measuring mechanical nociception in rodents using von Frey filaments

Figure 5

SUDO is valid for PWT estimation in rats. (A) Frequency distribution of the rat paw withdrawal threshold (PWT) estimates calculated using the method of Chaplan et al., ([3]; n = 300). (B) Strong correlation between PWT estimates determined using the method of Chaplan et al. [3] and SUDO. (C) Correlation between mouse PWT estimates calculated using six von Frey presentations (trials) and the method of Chaplan et al. [3]. (D) Effect of changing the adjustment factor in the simplified scoring method, demonstrating a peak correlation with an adjustment factor near 0.5. (E) Correlation between mouse PWT estimates calculated with the two methods when calculated as filament bending force. (F) Probability of a positive nocifensive response by a rat to the fifth through ninth von Frey filament presentation in all trials. Data in (F) are mean and 95% confidence interval.

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Molecular Pain

ISSN: 1744-8069

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