| Yo-Pro-1 uptake (IC 50, nM) | Ca 2+flux (IC 50, nM) | ||||||
---|---|---|---|---|---|---|---|---|
WT | 155Tyr | 348Thr | 496Ala | WT | 155Tyr | 348Thr | 496Ala | |
A-804598 | 21.77 ± 2.8 | 21.50 ± 5.8 | 15.5 ± 0.6 | ND | 20.81 ± 7.6 | 19.36 ± 6.9 | 40.7 ± 14.2 | 25.57 ± 1.6 |
A740003 | 332.83 ± 12.3 | 449.2 ± 12.7 | 415.9 ± 98.2 | ND | 507.87 ± 91.1 | 379.43 ± 135.1 | 720.75 ± 27.9 | 405.50 ± 81.7 |
AZ11645373 | 198.2 ± 42 | 342.6 ± 48.3 | 218.75 ± 113.5 | ND | 296.3 ± 98.5 | 510 ± 39.9 | 806.75 ± 249.3 | 412.40 ± 1.7 |