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Figure 3 | Molecular Pain

Figure 3

From: Activated spinal astrocytes are involved in the maintenance of chronic widespread mechanical hyperalgesia after cast immobilization

Figure 3

Intrathecal application of L-α-AA inhibits widespread mechanical hyperalgesia. Graphs show the time courses of the changes in bilateral mechanical hyperalgesia after two doses (75 and 150 nmol) of L-α-AA administration as compared to the vehicle (PBS) in the calf skin (A), calf muscle (B), hindpaw (C), and both sides of the tail (D) (n = 5–6, mean ± SEM). L-α-AA (75 nmol, 150 nmol) or vehicle (PBS) was injected intrathecally (arrows) just after measurements of baseline mechanical threshold (Before) at 5 weeks after cast removal, and the measurements were repeated 3 h and 24 h later. *p < 0.05 as compared with each vehicle treatment group by a mixed-design two-way ANOVA.

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Molecular Pain

ISSN: 1744-8069

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