Figure 5

LY354740 has no effect on neuronal excitability of CeLC neurons in the arthritis pain model. A: Current-clamp recordings of action potentials (top) generated in a CeLC neuron by direct (through the patch electrode) intracellular injections of current pulses (500 ms; bottom) of increasing magnitude before and during LY354740 administration. LY354740 (1 μM, 10 min) did not change action potential firing rate. B: Action potential firing rate measured by intracellular injection of current pulses of increasing magnitude (50 pA steps) was not significantly changed in the presence of LY354740 (1 μM) (n = 6). Symbols and error bars represent mean ± SE. For the measurement of action potential firing in current clamp, neurons were recorded at -60 mV.