From: Delayed sympathetic dependence in the spared nerve injury (SNI) model of neuropathic pain
Neuropathic pain model | sympX timing (related to nerve injury) | Type of sympX | Mechanical allodynia | Mechanical hyperalgesia | Heat hyper-sensitivity | Cold hyper-sensitivity |
---|---|---|---|---|---|---|
CCI | 5 d prior | Chemical GU | ↔ (a) | ↘↘↘ (a) | ↘↘↘ (a) | |
Intra-operative | Surgical | ↔/↗ (b,1) | ↘↘ (b) | ↘↘↘ (b) | ||
1 w after | Surgical | ↘ (k) | ↘ (k) | |||
10 d after | Chemical GU | ↘ (a) | ↘↘ (a) | ↘↘↘ (a) | ||
PSL | 7 and 4 d prior | Chemical GU | ↔ (c) | ↘ (c) | ||
Intra-operative | Chemical GU | ↗ (c,2) | ↗ (c,2) | |||
1 w after | Surgical | ↘ (k) | ↘ (k) | |||
7 m after | Chemical GU | ↘↘↘ (c) | ↘↘↘ (c) | |||
SNL L5 or SNL L5/L6 | 1 w prior | Surgical | ↘↘↘ (d) , ↔ (h) | ↘↘↘ (d) | ||
Intra-operative | Surgical | ↔ (g) | ↘ (f) | |||
Intra-operative | Chemical GU/PM | ↔ (g) | ||||
4 d after | Surgical | ↘↘↘ (f) | ↘↘ (d,e) | ↘ (k) , ↘↘↘ (e) | ||
1 w after | Surgical | ↘↘↘ (d,k,e,i) , ↔ (h) , ↘↘ (j) | ↘↘ (d) | |||
2 w after | Chemical GU/PM | ↘↘ (d) | ||||
3 w after | Surgical | ↘↘↘ (d) , ↔ (h) | ||||
5 w after | Surgical | ↘↘↘ (d) |