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Figure 3 | Molecular Pain

Figure 3

From: The activation of nicotinic acetylcholine receptors enhances the inhibitory synaptic transmission in the deep dorsal horn neurons of the adult rat spinal cord

Figure 3

Effects of nicotinic receptor agonists on mIPSCs in lamina V neurons. A, The consecutive traces of mIPSCs are in the control (left) and following the application of nicotine (100 μM, right). Two histograms on the bottom panel show the time course of changes in mIPSC frequency (left) and amplitude (right) during the application of nicotine; time bin is 10 s. B, C, Experiments were similar to that shown in (A) except that 100 μM RJR-2403 or 10 mM choline was tested. D, A histogram shows relative mIPSC frequency following the applications of nicotine (n = 11), RJR-2403 (n = 6), or choline (n = 7). mIPSC frequency before the applications of testing drugs is used as control and is scaled at 100%. Data represent Mean ± SEM; *P < 0.05; n.s., not significant.

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Molecular Pain

ISSN: 1744-8069

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