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Figure 4 | Molecular Pain

Figure 4

From: Requirement of extracellular signal-regulated kinase/mitogen-activated protein kinase for long-term potentiation in adult mouse anterior cingulate cortex

Figure 4

LTP induced by pairing and EPSP-AP protocols in the absence and presence of picrotoxin. A, B: In the absence of picrotoxin (No picrotoxin), LTP induced by the pairing protocol (n = 8) is significantly reduced compared to that in the presence of picrotoxin (Picrotoxin; n = 13, see Fig. 1B, D). PD98059 (50 μM, n = 6) blocks the pairing-induced LTP in the absence of picrotoxin (No picrotoxin + PD98059). * P < 0.05 compared with EPSC amplitude (%) in the absence of picrotoxin (No picrotoxin). C, D: LTP induced by the EPSP-AP protocol shows no difference between in the absence (No picrotoxin, n = 9) and presence (Picrotoxin, n = 8, see Fig. 2B, D) of picrotoxin.

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Molecular Pain

ISSN: 1744-8069

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