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Figure 6 | Molecular Pain

Figure 6

From: Activation of the neurokinin-1 receptor by substance P triggers the release of substance P from cultured adult rat dorsal root ganglion neurons

Figure 6

Effects of SP and GR73632 on COX-2 protein expression in cultured adult rat DRG neurons. (A) The time-dependence of COX-2 expression in cultured DRG neurons exposed to SP. (B) The protein levels of COX-2 in DRG neurons treated with GR73632, either alone or together with 1 μM CP-96,345, three MAP kinases cascades inhibitors (10 μM U0126, 15 μM SB203580 and 30 μM SP600125) or with 1 μM NS-398, PKC inhibitors (1 μM Gö6976, 1 μM bisindolymaleimide, 200 μM PKCε translocation inhibitor peptide) for 60 min were measured by Western blot analysis. All data have been normalized to the COX-2 expression level of control group. The data are expressed as the means ± S.E.M. (bars) from 4 (A) or 4 (B) separate experiments. *, ** and *** denote p < 0.05, 0.01 and 0.001, respectively.

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Molecular Pain

ISSN: 1744-8069

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