From: Molecular and cellular limits to somatosensory specificity
Channel | Thermal | Mechanical | Chemical | Blockers |
---|---|---|---|---|
TRPV1 | T>42°C | hyper-osmolarity (N-terminal variant), modulates mechanosensitivity | protons, capsaicin, resiniferatoxin, camphor, eugeneol, anandamide, lypooxygenases, 2-APB, clotrimazole, hydroxy-alpha-sanshool | Ruthenium Red (RR), capsazepine, BCTC, DD01050, iodo-resiniferatoxin, SB-452533, Cu:phenantroline |
TRPV2 | T>52°C | hypo-osmolarity | 2-APB, Δ9-THC, probenecid | RR, SKF96365 |
TRPV3 | T>30–39°C |  | camphor, 6-tert-butyl-m-cresol, carvacrol, eugenol, dihydrocarveol, thymol, carveol and (+)-borneol, 2-APB, arachidonic acid (AA); diphenylboronic anhydride | diphenyltetrahydrofuran, RR, |
TRPV4 | T>25–35°C | mechanical (sheer stress), hypo-osmolarity | 4α-PDD, anandamide, epoxyeicosatrienoic acids, bisandrographolide A | RR |
TRPM8 | T<23–28°C | membrane tension | menthol, eucalyptol, icilin, WS23, LPC | BCTC, SKF96365, clotrimazole, Cu:phenantroline, intracellular acidification, 2-APB |
TRPA1 | T<18°C | mechanical | icilin, cinnamaldehyde, mustard oil, allicin, BCTC, 2-APB, 4-hydroxynonenal, hydroxy-alpha-sanshool, acetaldehyde, Δ9-THC, formaldehyde, trinitrophenol, GsMTx-4, methyl p-hydroxybenzoate, menthol, Ca2+ | camphor, Gd3+, RR, gentamicin, amiloride, HC-030031, menthol, clorpromazine, AP18 |
TRPC1 | Â | mechanical | Â | Gd3+, La3+, 2-APB |
TRPC6 | Â | hypo-osmolarity | 1-oleolyl-2-acetyl-sn-glycerol | 2-APB |
ASIC1 | cold (positive modulator) | mechanical? | Protons | amiloride, aspirin, Psalmotoxin, A-317567 |
ASIC2 | Â | mechanical | Protons | amiloride, aspirin, A-317567 |
ASIC3 | cold (positive modulator) | mechanical | protons, lactic acid | amiloride, aspirin, APETx2, A-317567 |
P2X2 | Â | mechanical (modulates ATP release) | ATP, UTP | suramin |
P2X3 |  | mechanical (modulates ATP release) | ATP, α,β-meATP | suramin, A-317491, TNP-ATP |
TREK1 | heat | mechanical | AA, LPC, protons, riluzole, inhalation anesthetics, flufenamic acid | clorpromazine, diltiazem, bupivacaine, fluoxetine, sipatrigine |
TREK2 | heat | mechanical | AA, LPC, protons, riluzole, inhalation anesthetics, Zn2+, flufenamic acid | Pb2+, diltiazem |
TASK1 |  |  | inhalation anesthetics | protons, Zn2+, hypoxia, anandamide, Gα q |
TASK3 |  |  | inhalation anesthetics | protons. Zn2+, Ba2+, RR, anandamide, Gα q |