Table 1 Quantitative analysis of microglia density and percentage of particular microglia type in pain-related brain structures (Ipsi. and Contral. indicate surgery and intact sides, respectively).
| Â | Â | Â | Â | Cell type (%) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Region | Â | Density (number/mm 2 ) | Ramified | Hypertrophied | Mono-polar | Bipolar | |||||
| Â | Â | Ipsi. | Contral. | Ipsi. | Contral. | Ipsi. | Contral. | Ipsi. | Contral. | Ipsi. | Contral. |
ACC | control | 191.0 ± 27.6 | 200.0 ± 38.4 | 95.7 ± 0.3 | 94.4 ± 0.5 | 0 | 0 | 4.3 ± 0.3 | 4.4 ± 0.3 | 0 | 1.2 ± 0.4 |
|  | injury | 181.7 ± 13.6 | 188.7 ± 13.5 | 92.1 ± 0.4 | 92.3 ± 1.7 | 0 | 0 | 5.7 ± 0.3 | 4.4 ± 0.2 | 2.2 ± 0.7 | 3.3 ± 1.7 |
Prefrontal | control | 193.3 ± 27.6 | 199.7 ± 28.9 | 94.6 ± 0.9 | 95.6 ± 0.9 | 0 | 0 | 4.1 ± 0.4 | 4.3 ± 0.9 | 1.3 ± 0.2 | 0 |
Cortex | injury | 184.7 ± 14.5 | 180.3 ± 18.9 | 89.9 ± 2.5 | 90.1 ± 2.2 | 2.6 ± 1.5 | 0 | 6.3 ± 0.3 | 7.3 ± 1.3 | 1.2 ± 0.7 | 2.6 ± 1.4 |
Somatosensory | control | 169.3 ± 17.6 | 152.0 ± 17.6 | 97.2 ± 0.9 | 98.8 ± 0.5 | 0 | 0 | 2.1 ± 0.5 | 1.2 ± 0.5 | 0.7 ± 0.4 | 0 |
Cortex | injury | 184.0 ± 24.5 | 178.3 ± 13.6 | 92.8 ± 2.4 | 94.9 ± 0.6 | 0 | 0 | 4.5 ± 2.1 | 5.1 ± 0.6 | 2.7 ± 0.6 | 0 |
Insular cortex | control | 189.0 ± 11.8 | 209.2 ± 16.8 | 94.5 ± 0.6 | 96.6 ± 0.6 | 0 | 0 | 4.8 ± 0.3 | 2.9 ± 0.3 | 0.7 ± 0.3 | 0.5 ± 0.5 |
|  | injury | 176.7 ± 22.6 | 174.3 ± 18.2 | 98.0 ± 0.3 | 96.3 ± 0.6 | 0 | 0 | 1.5 ± 0.3 | 2.7 ± 0.3 | 0.5 ± 0.3 | 1.0 ± 0.6 |
Amygdala | control | 194.0 ± 21.7 | 176.7 ± 26.3 | 94.2 ± 1.2 | 98.0 ± 1.3 | 1.1 ± 0.6 | 0 | 2.6 ± 0.2 | 2.0 ± 1.3 | 2.1 ± 0.6 | 0 |
|  | injury | 184.3 ± 12.5 | 183.3 ± 14.2 | 93.9 ± 1.8 | 96.3 ± 2.0 | 0 | 0 | 3.3 ± 0.9 | 3.7 ± 2.0 | 2.7 ± 0.9 | 0 |
Hippocampus | control | 182.3 ± 20.8 | 183.3 ± 13.6 | 93.3 ± 0.7 | 92.5 ± 0.9 | 0 | 0 | 4.3 ± 0.7 | 4.3 ± 0.5 | 2.4 ± 0.4 | 3.2 ± 0.5 |
|  | injury | 176.3 ± 12.7 | 185.0 ± 15.0 | 91.1 ± 2.3 | 88.7 ± 2.2 | 0 | 1.5 ± 0.6 | 7.0 ± 1.2 | 6.7 ± 0.6 | 1.9 ± 1.2 | 3.1 ± 3.0 |
Thalamus | control | 145.4 ± 34.1 | 124.2 ± 37.1 | 96.6 ± 0.6 | 94.0 ± 0.9 | 0 | 0 | 3.4 ± 0.6 | 4.5 ± 0.9 | 0 | 1.5 ± 0.2 |
|  | injury | 131.3 ± 46.5 | 139.4 ± 37.9 | 86.7 ± 2.3 | 89.8 ± 2.1 | 0 | 0 | 6.6 ± 1.2 | 7.3 ± 1.2 | 6.7 ± 1.2 | 2.9 ± 0.9 |
PAG | control | 105.7 ± 12.3 | 104.0 ± 20.4 | 92.7 ± 2.6 | 90.4 ± 3.1 | 0 | 0 | 4.0 ± 1.6 | 7.6 ± 1.6 | 3.3 ± 1.1 | 1.9 ± 0.8 |
|  | injury | 130.0 ± 25.0 | 125.3 ± 15.5 | 88.4 ± 1.8 | 86.1 ± 2.3 | 0 | 0 | 7.3 ± 1.2 | 7.5 ± 1.4 | 4.3 ± 0.8 | 6.4 ± 1.0 |
RVM | control | 79.3 ± 12.5 | 77.7 ± 17.0 | 91.8 ± 0.9 | 90.5 ± 1.2 | 0 | 0 | 5.1 ± 0.3 | 4.3 ± 0.3 | 3.1 ± 0.6 | 5.2 ± 0.9 |
|  | injury | 78.7 ± 14.6 | 82.3 ± 12.3 | 89.5 ± 2.6 | 91.3 ± 0.7 | 0 | 0 | 6.4 ± 1.4 | 4.0 ± 0.9 | 4.1 ± 1.2 | 4.7 ± 0.7 |