Figure 6

Alteration of the steady-state inactivation of TTX-R and TTX-S Na⁺ currents in slow and fast small DRG neurons after CCD and CCI treatment. A and B: Representative records of the inactivation current from a slow neuron (A) and a fast neuron (B) from a control DRG. The currents were recorded by using a double protocol with a 500 ms prepulse ranging from -120 mV to -10 mV (in 5 mV increments), followed by, with a 0.8 ms interpulse interval to -80 mV, a test pulse to -10 mV. The inter-pulse period was 10 s. The TTX-R inactivation currents were measured at the time of the peak current evoked following a -50 mV prepulse. The TTX-S inactivation currents were measured at the time of the peak of the maximum current evoked following a -120 mV prepulse. Each data set was normalized and fit with a Boltzman equation. The best fitted steady-state inactivation curves were showed in C-F.