Figure 7

RTX blocks capsaicin-induced efferent neurogenic inflammation. Following Evans blue injection (i.v., 30 mg/kg, 2% solution), a 1% capsaicin cream was liberally applied to the shaved hind legs and paws. Areas of neurogenic-induced plasma extravasation are seen as blue. Note the delineation between the blue area (positive for plasma extravasation) versus the white skin (negative for plasma extravasation) for the RTX treated side (A, C) and extravasation on only the three medial toes for the RTX-treated side. Perineural vehicle application did not effect plasma extravasation (B). These data indicate selective targeting of the sciatic nerve while preserving the saphenous division via this percutaneous injection.