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Figure 5 | Molecular Pain

Figure 5

From: The chemokine CXCL1/growth related oncogene increases sodium currents and neuronal excitability in small diameter sensory neurons

Figure 5

Effect of the protein synthesis inhibitor cycloheximide (CHX) on enhancement of Na+ currents by GRO/KC incubation. Cycloheximide (3.5 μM) or vehicle (DMSO) was added to cell cultures just before addition of 1.5 nM GRO/KC or vehicle, and TTX-S and TTX-R Na currents were measured 16 to 30 hours later. *, significantly different from all other groups; #, significantly different from control (one-way ANOVA followed by Tukey's multiple comparison test). Data are from 1 set of experiments (3 cultures) comparing 22 control and 29 CHX treated cells, and a second set of experiments (2 cultures) comparing 14 GRO/KC treated cells with 22 GRO/KC + CHX treated cells. Additional data, from Figure 1, are included in the control and GRO/KC data groups. Analysis omitting this additional data gave similar results, except that the TTX-R current in IB4-positive cells showed no significant differences between groups.

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Molecular Pain

ISSN: 1744-8069

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