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Figure 1 | Molecular Pain

Figure 1

From: The role of TRPV1 in different subtypes of dorsal root ganglion neurons in rat chronic inflammatory nociception induced by complete Freund's adjuvant

Figure 1

Antagonizing effect of AMG 9810, a specific TRPV1 antagonist, on thermal hyperalgesia and mechanical allodynia on day 7 after CFA injection. A, C, and E in left panel for thermal hyperalgesia presented by hot plate latency (HPL); B, D and F in right panel for mechanical allodynia presented by paw withdrawal latency (PWT). A, Hot plate latency (HPL); C, Reversal of HPL (%); E, Area under the curve (AUC) of percentage of reversal of HPL. B, Paw withdrawal threshold; D, % Reversal of PWT; F, Area under the curve (AUC) of percentage of reversal of PWT. After AMG 9810 application, HPL and % reversal of HPL significantly increased at doses of 5 to 45 μg (p < 0.05, 0.01 or 0.001) from 1 h to 4 h; PWT and the reversal of PWT (%) displayed similar results, the reversal of HPL (%) significantly increased at doses of 5 to 45 μg (p < 0.05 or 0.01) at 4 h. *, $ and # represent comparison of AMG 9810 at 5, 15 or 45 μg with vehicle, respectively. n = 5–13.

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Molecular Pain

ISSN: 1744-8069

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