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Figure 1 | Molecular Pain

Figure 1

From: Origins, actions and dynamic expression patterns of the neuropeptide VGF in rat peripheral and central sensory neurones following peripheral nerve injury

Figure 1

Increased VGF mRNA expression in L4/5 DRG and dorsal horn following SNI. A. QPCR analysis of VGF mRNA in ipsilateral L4/5 DRG from naïve and 3, 7 and 21 days post-SNI. Data is expressed as the mean fold change ± standard deviation normalised to naïve values (* p ≤ 0.05, ANOVA, n = 8 per group). B In situ hybridization histochemistry of L4/5 DRG showing the change in VGF mRNA expression post-injury. C Quantification of in situ hybridization data showing the mean number of ipsilateral and contralateral DRG cells expressing VGF mRNA and the mean density of silver grains at 7 and 21 days post-SNI (* p ≤ 0.05, ANOVA, Dunnetts post-hoc test, n = 4 per group). D. QPCR analysis of VGF mRNA from L4/5 naïve and ipsilateral dorsal horn quadrants, 3, 7 and 21 days post-SNI. Data is expressed as the mean fold change ± standard deviation and normalised to naïve values (*p ≤ 0.05, ANOVA, n = 8 per group). E. In situ hybridization of VGF mRNA in L4/5 spinal cord at 7 days post-SNI.

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Molecular Pain

ISSN: 1744-8069

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