Skip to main content
Figure 1 | Molecular Pain

Figure 1

From: Nitric oxide activates ATP-sensitive potassium channels in mammalian sensory neurons: action by direct S-nitrosylation

Figure 1

Single-channel characteristics of K ATP channel in DRG neurons dissociated from SS and SNL rat. (A) Representative current traces of KATP channels in SS or SNL neurons recorded in cell-attached configuration at a holding potential of -60 mV. In SS and SNL neurons, bath application of DNP (100 μM) activated KATP channel, and this channel activity was inhibited by glybenclamide (1 μM). The changes of NPo values are summarized in (B). Values are shown as mean ± SD (n = 8 each). (C) Representative KATP current traces in SS or SNL neurons recorded in inside-out configuration at a holding potential of -60 mV. ATP (1 mM) was added to the intracellular solution as indicated by the horizontal solid bar. Arrows indicate closed channel state.

Back to article page

Molecular Pain

ISSN: 1744-8069

Contact us