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Figure 7 | Molecular Pain

Figure 7

From: Nitric oxide activates ATP-sensitive potassium channels in mammalian sensory neurons: action by direct S-nitrosylation

Figure 7

Effects of thiol-modifying agents on NO-induced K ATP channel activation. (A) Representative current traces in inside-out patches at -60 mV holding potential in the presence of 1 mM [ATP]i in large SS neurons. SNAP (100 μM) and DTT (5 mM), a thiol-reducing agent, were added to bath solution as indicated by the horizontal solid bars. Arrows indicate closed channel state. The changes of NPo values are summarized in (B). Values are shown as mean ± SD (n = 7 in each group). (C) Representative current traces in inside-out patches at -60 mV holding potential in the presence of 1 mM [ATP]i in large SS neurons. NEM (5 mM), a thiol alkylating agent, and SNAP (100 μM) were added to bath solution as indicated by the horizontal solid bars. Arrows indicate closed channel state. The changes of NPo values are summarized in (D). Values are shown as mean ± SD (n = 6 in each group).

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Molecular Pain

ISSN: 1744-8069

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