Figure 7
From: Antidepressants inhibit P2X4 receptor function: a possible involvement in neuropathic pain relief
Effect of spinal 5-HT depletion on the antiallodynic effect of paroxetine. 5-HT immunoreactivity in the dorsal horn of the spinal cord nine days after intrathecal injection of either saline or 5,7-dihydroxytryptamine (a). A marked reduction in the number of 5-HT immunoreactive fibres was observed in the dorsal horn of the L5 spinal cord after 5,7-DHT treatment compared with the saline-treated group. No significant change in the antiallodynic effect of paroxetine was observed in the 5,7-DHT-treated group compared with the saline-treated group (b). (p > 0.05 by a Dunn's multiple comparison test after a Friedman test.) Data are means ± SEM of 5–6 rats.