Figure 2
From: Reactive oxygen species mediate TNFR1 increase after TRPV1 activation in mouse DRG neurons
Capsaicin or resiniferatoxin activation of TRPV1 increases TNFR1 staining in cultured mouse DRG neurons. Histograms show the percentage of immunoreactive cells in DRG neuronal cultures. (A) Capsaicin (CAP) significantly increases TNFR1 staining (*P < 0.05) and capsazepine (CAPP) blocks TNFR1 staining increases induced by capsaicin (# P < 0.05 compared to capsaicin alone). (B) Resiniferatoxin (RFT) significantly increases TNFR1 (**P < 0.01) and capsazepine blocks the TNFR1 increase induced by resiniferatoxin (## P < 0.01 compared to resiniferatoxin alone). (C) There is no change of TNFR1 in DRG neurons from TRPV1 knockout mice after capsaicin or resiniferatoxin stimulation.