Chemokine | Sham | gp120/hCD4 | gp120/hCD4 +ddC |
---|
MCP1
| 3.2% |
18.7%*
|
17.5% *
|
SDF1
| 4.8% | 4.3% |
40%**
|
IP10
| 6.5% | 5.9% | 7.5% |
- *p < 0.05 and ** p < 0.01 when compared to sham
- Minimum of 50 cells/treatment group
- Calcium imaging was used to monitor the change in [Ca2+]i after chemokines were applied to acutely dissociated DRG from sham or injured rats. The number of cells responding to MCP1 application increased significantly by 21 days after gp120/hCD4 and following the combination of gp120/hCD4 and ddC treatment. The number of cells responding to SDF1 application increased only after the combination of gp120/hCD4 and ddC treatments.