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Figure 5 | Molecular Pain

Figure 5

From: Ryanodine receptors contribute to the induction of nociceptive input-evoked long-term potentiation in the rat spinal cord slice

Figure 5

Caffeine-induced LTP of fEPSPs in spinal cord slice. A, After perfusion with 10 mM caffeine for 2 min instantly following washed out, LTP of fEPSPs occurred without conditioning stimulation in the presence of 10 μM bicuculline methiodide and 1 μM strychnine, which lasted for more than 80 min. Inserts show original recordings 5 min before (1) and about 80 min after (2) 10 mM caffeine challenge. Traces were not averaged (n = 13). B, Perfusion with 20 μM ryanodine 1 hour before caffeine challenge blocked the induction of LTP of fEPSPs. Inserts show original recordings without averaging (n = 5).

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Molecular Pain

ISSN: 1744-8069

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