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Figure 2 | Molecular Pain

Figure 2

From: Gi- and Gq-coupled ADP (P2Y) receptors act in opposition to modulate nociceptive signaling and inflammatory pain behavior

Figure 2

P2Y Gi receptor immunoreactivity is localized in sensory neurons of the DRG. Staining for P2Y12 (A), P2Y13 (B) and P2Y14 (C) in cryostat sections of DRG neurons double-labeled for the high-molecular weight neurofilament protein, NFH, used as a marker of neurons with myelinated axons. Antibodies for all three receptors intensely stain small-diameter, NFH-negative neurons. However, P2Y12 expression is largely restricted to NFH-negative neurons, whereas P2Y13 and P2Y14 are expressed in some NFH-positive sensory neurons (arrowheads). n = 3 mice, > 400 cells/antibody.

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Molecular Pain

ISSN: 1744-8069

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