Receptor | Signaling | Preferred Agonist | ΔCT (DRG) |
---|
P2Y1* | Gq/11 | ADP | 6.22 ± 0.11 |
P2Y2* | Gq/11 | ATP = UTP | 6.17 ± 0.08 |
P2Y4*‡
| Gq/11 | ATP = UTP | 13.63 ± 0.31 |
P2Y6* | Gq/11 | UDP | 10.92 ± 0.14 |
P2Y12 | Gi/o | ADP | 7.55 ± 0.26 |
P2Y13** | Gi/o | ADP = IDP | 9.78 ± 0.59 |
P2Y14 | Gi/o | Glycosylated UDP | 7.91 ± 0.59 |
- Relative expression levels of mRNA for P2Y family members in DRG are expressed as the normalized cycle threshold (ΔCT): the P2Y CT value minus the CT for the reference standard, GAPDH. *Previously published data [28]. ‡Rodent P2Y4 receptor shows equivalent responsiveness to ATP and UTP; the human receptor is selective for UTP. **Mouse but not human P2Y13 shows high affinity for IDP as well as ADP. P2Y11 is not included here because it is not expressed in rodents. (See [10, 37–39]).