Figure 8From: Nociceptive stimulation induces expression of Arc/Arg3.1 in the spinal cord with a preference for neurons containing enkephalin Naïve Arc/Arg3.1 knockout (KO) mice showed significantly longer response times on the hotplate than their naïve wild type (WT) littermates. A and B, Histogram showing the mechanical threshold (A) and thermal withdrawal latency (B) of Arc/Arg3.1 KO and WT mice, assessed with the Von Frey and the hotplate test, respectively. Error bars represent ± SEM. *: p < 0.05, unpaired t-test; n = 4 for A and for B.Back to article page