Figure 2From: Activation of voltage-gated KCNQ/Kv7 channels by anticonvulsant retigabine attenuates mechanical allodynia of inflammatory temporomandibular joint in rats Development of mechanical allodynia in TMJ induced by CFA in rats. Head withdrawal threshold was measured using an electric von Frey anesthesiometer over a 96-hour period for the saline control group (open squares) and the CFA group (filled triangles). CFA was injected at time 0 and the withdrawal threshold was measured at time points 6 h, 12 h, 24 h, 48 h, and 96 h. The lowest head withdrawal threshold occurred 12 h after CFA injection and was maintained for about 36 h (P < 0.001 for time period of 12 to 96 hours, compared with the saline group, two-way ANOVA).Back to article page