Figure 1

The involvement of caspase-1 in mechanical inflammatory hypernociception. (A) Mechanical nociceptive threshold of wild type and casp1-/- mice using the electronic von Frey. (B) Wild type or casp1-/- mice received an intraplantar injection of carrageenin (100 μg/paw). Mechanical hypernociception was evaluated 3 and 5 h after carrageenin injection. (C) Mice were pretreated with a caspase-1 inhibitor (YVAD-CMK, 1-9 mg/kg s.c. 30 min before) followed by intraplantar injection of carrageenin (100 μg/paw). Mechanical hypernociception was evaluated 3 h after carrageenin injection. Data are expressed as the mean ± S.E.M. of 5 animals per group. * indicates statistical significance compared to the saline injected group; # statistical significance compared to wild type or vehicle-treated group. P < 0.05, one-way ANOVA followed by the Bonferroni's test.