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Figure 4 | Molecular Pain

Figure 4

From: Pain-related increase of excitatory transmission and decrease of inhibitory transmission in the central nucleus of the amygdala are mediated by mGluR1

Figure 4

GABAergic inhibition is lost in a model of arthritic pain. (A) A GABAA receptor antagonist (bicuculline, 10 μM) significantly increased I/O function of EPSCs evoked in CeLC neurons in slices from normal rats (n = 5 neurons, P < 0.001, two-way ANOVA; see Results). Individual traces show EPSCs evoked in one CeLC before (Predrug) and during bicuculline. Stimulus intensity, 0.9 mA. Scale bars: 50 pA, 10 ms. (B) Bicuculline had no significant effect on EPSCs recorded in CeLC neurons in slices from arthritic rats (n = 5 neurons, P > 0.05, two-way ANOVA; see Results). Traces show EPSCs recorded in one CeLC neuron before (Predrug) and during bicuculline; they were nearly identical as bicuculline had no effect. Stimulus intensity, 0.9 mA; scale bars, 50 pA, 10 ms. (C) Bar histograms show the significantly greater facilitatory effect of bicuculline on EPSCs (normalized to predrug; set to 1.0) in slices from normal rats compared to arthritic rats. * P < 0.05, unpaired t- test. (A-C) Symbols and error bars represent means ± SE.

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Molecular Pain

ISSN: 1744-8069

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