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Figure 6 | Molecular Pain

Figure 6

From: The contribution of spinal glial cells to chronic pain behaviour in the monosodium iodoacetate model of osteoarthritic pain

Figure 6

Minocycline attenuates microglia and astrocyte activation in MIA-treated rats. A: Minocycline treatment (30 mg.kg-1) significantly attenuated MIA-induced increases in Iba-1 positive activated microglia in the ipsilateral dorsal horn at day 28, compared to the effects of vehicle treatment in MIA-injected rats. B: Minocycline treatment (30 mg.kg-1) significantly attenuated MIA-induced increases in GFAP immunofluorescence in the ipsilateral dorsal horn at day 28, compared to MIA-treated rats which received vehicle. Data are expressed as mean ± SEM. Statistical analyses comparing effects of minocycline treatment versus vehicle were performed using a Student's t test: **p < 0.01. ***p < 0.001.

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Molecular Pain

ISSN: 1744-8069

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