Figure 2From: Acute cold hypersensitivity characteristically induced by oxaliplatin is caused by the enhanced responsiveness of TRPA1 in mice Neither cisplatin nor paclitaxel induces acute mechanical and cold hypersensitivity. Mice were intraperitoneally administered vehicle, cisplatin (5 mg/kg; A, B), or paclitaxel (6 mg/kg; C, D), and 2 h later the 50% withdrawal threshold to mechanical stimulation ( A, C) and the escape behaviors in response to cold stimulation ( B, D) were evaluated. Data are presented as the means ± S.E.M. of 6 mice.Back to article page