Figure 8
Effects of 5-HT 3 receptor agonist and antagonist on sIPSCs. (A) Sample trace of sIPSCs recorded before, during and after the application of mCPBG (30 μM). Lower traces show sIPSCs before (left) and after (right) the application of mCPBG in the expanded time scale. (B) In the same neuron from (A), sample trace of sIPSCs recorded before ICS-205,930 (10 μM), during and after the application of mCPBG in the presence of ICS-205,930. Lower traces show sIPSCs before (left) and after (right) the application of mCPBG in the presence of ICS-205,930 in the expanded time scale. The bar graph shows the relative frequency (C) and amplitude (D) for mCPBG, ICS-205,930 and mCPBG + ICS-205,930, respectively (paired t-test, ** P < 0.01 and *P < 0.05, n = 7).