Figure 1From: Expression of Nav1.7 in DRG neurons extends from peripheral terminals in the skin to central preterminal branches and terminals in the dorsal horn Expression of Nav1.7 in DRG neurons. A. DRG sections were reacted to antibodies against peripherin, neurofilament 200 (NF) and Nav1.7. Peripherin-positive (green) neurons are generally of small diameter (<30 μm) and most exhibit colocalization (yellow) with Nav1.7 (red). A few small peripherin-negative neurons display robust Nav1.7 immunolabeling (arrows). Neurofilament 200 (NF)-positive (blue) neurons are generally larger than peripherin-positive cells and most do not display colocalization with Nav1.7. A few smaller NF-positive cells exhibit Nav1.7 immunolabeling (magenta). B. DRG sections were reacted with IB4-488 and antibodies to CGRP and Nav1.7. Virtually all IB4-positive (green) neurons display colocalization (yellow) with Nav1.7. Similarly, nearly all CGRP-positive (blue) neurons exhibit colocalization (magenta) with Nav1.7 (red). Few DRG neurons (arrow) display colocalization of IB4, CGRP and Nav1.7.Back to article page