Figure 2From: Expression of Nav1.7 in DRG neurons extends from peripheral terminals in the skin to central preterminal branches and terminals in the dorsal horn Expresion of Nav1.7 in sciatic nerve. A. Numerous peripherin-positive (green) unmyelinated fibers are immunolabeled in sciatic nerve and these fibers exhibit extensive colocalization (yellow) with Nav1.7 (red). Inset. At increased magnification, peripherin-positive (green) fiber displays colocalization (yellow) with Nav1.7. B. Nodal regions in sciatic nerve were identified by paranodal caspr (green) labeling. Nav1.7 (red) immunolabeling at a node is displayed by a small diameter (<1 μm) myelinated fiber. Not all small diameter myelinated fibers exhibit Nav1.7 labeling at nodes.Back to article page