Time of testing (min) | | | | |
---|
Concentration | von Frey (g) | Baseline | 30 | 60 |
---|
0.25 μg/paw
| | | | |
WT mice | 0.81±0.04 | 1.00±0.00 | 0.49±0.15b | 0.39±0.07b |
hph mice | 0.78±0.04a | 1.00±0.00 | 0.44±0.10a,b | 0.47±0.07a,b |
0.5 μg/paw
| | | | |
WT mice | 0.81±0.08 | 1.00±0.00 | 0.26±0.03b | 0.28±0.11b |
hph mice | 0.80±0.10a | 1.00±0.00 | 0.28±0.11a,b | 0.26±0.03a,b |
1 μg/paw
| | | | |
WT mice | 1.03 ± 0.09 | 1.00±0.00 | 0.18±0.04b | 0.19±0.03b |
hph mice | 0.99 ± 0.04a | 1.00±0.00 | 0.42±0.10b,c | 0.39±0.07b,c |
- The results are expressed as relative pain behaviour (normalised to the baseline response of each mouse). For 0.25, 0.5 and 1 μg/paw n = 3–6, n = 4 and n = 6–10, respectively. The letter a, indicates non-significant differences when compared to WT mice (p > 0.05), the letter b, indicates significant differences compared to baseline, and the letter c, indicates significant differences relative to WT (p < 0.05). Unpaired t-test (two-tailed) or two-way RM-ANOVA with Fisher’s LSD test. Data is shown as mean ± SEM.