An important reference on the identification of specific PKC phosphorylation site in mu-opioid receptors.
Li-Yen Huang, University of Texas Medical Branch
6 January 2014
Feng et al (2011)* showed that S363 is a major PKC phosphorylation site on mu-opioid receptors (μ-MORs). The PKC-mediated phosphorylation of the site interrupts receptor-G protein coupling, thus promoting the desensitization of μ-MORs
*Feng B, Li Z Wang JB: Protein kinase C-mediated phosphorylation of the mu-opioid receptor and its effects on receptor signaling.Molecular pharmacology 2011, 79: 768-775.
An important reference on the identification of specific PKC phosphorylation site in mu-opioid receptors.
6 January 2014
Feng et al (2011)* showed that S363 is a major PKC phosphorylation site on mu-opioid receptors (μ-MORs). The PKC-mediated phosphorylation of the site interrupts receptor-G protein coupling, thus promoting the desensitization of μ-MORs
*Feng B, Li Z Wang JB: Protein kinase C-mediated phosphorylation of the mu-opioid receptor and its effects on receptor signaling. Molecular pharmacology 2011, 79: 768-775.
Competing interests
None declared