Figure 4
From: Polysulfide evokes acute pain through the activation of nociceptive TRPA1 in mouse sensory neurons
[Ca2+]i responses to polysulfide in TRPV1(−/−) and TRPA1(−/−) mouse DRG neurons. Actual recordings of [Ca2+]i responses to sequential application of Na2S3 (10 μM), allylisothiocyanate (AITC, 0.3 mM), capsaicin (Cap, 1 μM), and KCl (K, 80 mM) in TRPV1(−/−) (A) and TRPA1(−/−) (B) mouse DRG neurons. (C) Columns showing the % responding cells among all neurons in each animal. Columns with vertical lines show mean ± SEM (wild type; n = 322, TRPV1(−/−); n = 278, TRPA1(−/−); n = 253, from 3–5 mice for each genotype). **P, < 0.01.