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Fig. 5 | Molecular Pain

Fig. 5

From: Transient, activity dependent inhibition of transmitter release from low threshold afferents mediated by GABAA receptors in spinal cord lamina III/IV

Fig. 5

Gabazine-induced increase of PPR is not an indirect effect of postsynaptic GABAA receptor activation. a Perfusion of lamina III/IV neurons with a CsF-based intracellular solution inhibits muscimol-induced current compared to that observed in intracellular Cs-methanesulfonate. b, c The presence of intracellular CsF does not prevent the effect of gabazine on the second eEPSC amplitude in a lamina III/IV neuron. b averaged traces from five consecutive EPSCs recorded in control and in gabazine 10 μM. c Mean peak amplitudes of the four EPSCs recorded from the neuron represented in b. d Population data (from a total of eight cells) comparing the change in the second peak as a function of control PPR. e Shows the PPR plotted before and after gabazine when control PPR is <0.43 or >0.43. Only at synapses with PPRctl <0.43 gabazine causes a significant increase of PPR (paired t test, p = 0.006, n = 4)

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Molecular Pain

ISSN: 1744-8069

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