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Figure 1 | Molecular Pain

Figure 1

From: A transcription factor for cold sensation!

Figure 1

Selective genetic abolishment of cold sensation in NGFIB knockout mice. a-b. Behavioral responses of wild-type littermates (WT) and NGFIB knockout (NGFIB-/-) mice in the spinal tail-flick test (a) and the hot-plate test (b). c. Behavioral responses of WT and NGFIB-/- mice in the hot-plate test with different plate temperatures. No significant difference was detected between two groups. d. Behavioral responses of WT and NGFIB-/- mice to mechanical pressure applied to that tail. e. Behavioral responses of WT, NGFIB-/- and NGFIA-/- mice on the cold-plate (0°C). Response latencies of NGFIB-/- mice were significantly reduced as compared with WT littermates or NGFIA-/- mice. * P < 0.05 as compared with WT littermates or NGFIA-/- mice. f. Behavioral responses in the cold-plate test after repetitive measurements performed at 5 min intervals. While WT mice showed significant sensitization (i.e., significant reduction in response latencies), NGFIB-/- mice showed not sensitization. *. P < 0.05 compared with the first behavioral response latency. g. Immunostainings of CGRP-positive labels in the spinal cord lumbar dorsal horn of WT and NGFIB-/- mice.

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