Skip to main content
Figure 2 | Molecular Pain

Figure 2

From: Pre-injury administration of morphine prevents development of neuropathic hyperalgesia through activation of descending monoaminergic mechanisms in the spinal cord in mice

Figure 2

Involvement of supra-spinal MOPs in the pre-injury morphine-induced analgesic effects. A,B: Blockade of pre-injury morphine (10 mg/kg, s.c.)-induced analgesia by pretreatment with s.c. (1 mg/kg) or i.c.v. (1 nmol), but not i.t. (10 nmol), injection of the μ-opioid receptor antagonist naloxone in thermal paw withdrawal (A) and mechanical paw pressure (B) tests. Thermal paw withdrawal latencies (PWL) or mechanical paw withdrawal thresholds (PWT) were measured at 7 days following nerve injury. 'Morph' is morphine. Each data represents mean ± SE from 6–7 mice; *p < 0.05 compared with the vehicle pretreatment. 'Veh' indicates group of mice receiving only vehicle saline before nerve injury operation.

Back to article page

Molecular Pain

ISSN: 1744-8069

Contact us