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Figure 1 | Molecular Pain

Figure 1

From: Propofol suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABAA receptor chloride channels

Figure 1

Synaptic temporal summation in VB relay neurons. A: a photomicrograph of a live brain slice containing the ventrobasal (VB) complex, reticular thalamic nucleus (RTN), and other regions with which VB has synaptic connections. Thalamocortical slices were cut at 55° (Agmon and Connors, 1991). B: both tonic and rebound burst firing patterns were initiated in a VB neuron with intracellular current pulses (protocol not shown). A distinct membrane voltage response is characterized by a prominent sag and after-depolarization potential (ADP) in response to hyperpolarizing current pulses. The value to the left of the trace indicates membrane potential (mV) here and throughout. C: EPSPs showing temporal summation were evoked by extracellular stimulation of corticothalamic fibers in the white matter (a train of 5 pulses, 33 Hz, 0.15 ms). D: evoked EPSPs could be blocked by CNQX/AP5. E: group data demonstrating that EPSP temporal summation is frequency-dependent (n = 10).

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Molecular Pain

ISSN: 1744-8069

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