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Table 1 Effects of propofol on integrative properties of evoked EPSPs in thalamic VB neurons.

From: Propofol suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABAA receptor chloride channels

 

Slope (mV/ms)

1/2 width (ms)

Decay time (ms)

control

1.8 ± 0.4

14.5 ± 2.6

13.2 ± 2.8

propofol

1.6 ± 0.4

6.3 ± 0.4**

16.3 ± 3.2*

+ bicuculline

1.9 ± 0.5

13.5 ± 2.1

12.2 ± 2.4

  1. EPSPs are evoked by extracellular stimulation of corticothalamic fibers (a train of 5 pulses, 0.15 ms, 33 Hz). Data are derived from experiments as described in Fig. 2. Slope (dv/dt) representing depolarization rate is measured from the rising phase (20–80%) of the first EPSP. 1/2 width is measured at 50% of peak amplitude; decay time (20–80%) representing repolarization rate is measured from the falling phase of the fifth EPSP. *, P < 0.05. **, P < 0.001, vs. control.