Skip to main content
Figure 4 | Molecular Pain

Figure 4

From: Genetic alteration of anxiety and stress-like behavior in mice lacking CaMKIV

Figure 4

Restraint and cold swim stress. a, c, Antinociceptive responses in the hot-plate (n = 8 wild-type mice, n = 9 CaMKIV-/- mice, F(1,7) = 68.21, P < 0.01) and tail-flick test (F(1,7) = 13.59, P < 0.01) following restraint stress (30 min) was significantly decreased in CaMKIV-/- mice. b, d, antinociceptive effect presented as area under the curve between 0 to 60 min after restraint stress in the hot-plate test (t(15) = 4.13, P < 0.001) and tail-flick test (t(15) = 2.86, P < 0.05) show a lack of stress-induced analgesia in CaMKIV-/- mice. e, f, Similarly, hotplate responses after cold-swim test (n = 11 wild-type mice, n = 12 CaMKIV-/- mice) was significantly reduced in CaMKIV-/- mice (F(1,6) = 7.39, P < 0.05, area under the curve, t(21) = 2.26, P < 0.05)

Back to article page