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Table 3 Genes with significant adult inflammation-induced alterations in their expressions in the left LDH (ipsilateral to the CFA-inflamed neonatally-injured hindpaw) in CAR-P3 rats as compared to those in the left LDH of CONT and CAR-P12 animals after inflammation of the corresponding paw [one-way ANOVAs, (with the Benjamini and Hochberg's FDR correction procedure set at the P-value cutoff of 0.05) followed by Tukey's post-hoc tests (with the same P-cutoff value) in the implementation of GeneSpring GX software (Agilent, Palo Alto, CA).)]. Differences in gene expression are presented as ratios between CAR-P3 and CONT, CAR-P12 and CONT, and CAR-P3 and CAR-P12 groups. Statistically insignificant differences are marked as 'ND' The comparisons are based on the microarray profiling that employed 5 slides for comparison of CONT and CAR-P3 samples and another 5 slides for comparison of CONT and CAR-P12 samples.

From: Neonatal local noxious insult affects gene expression in the spinal dorsal horn of adult rats

Left LDH (ipsilateral to the site of neonatal injury)

Genes

CAR-P3/CONT

CAR-P12/CONT

CAR-P3/CAR-P12

Genes

CAR-P3/CONT

CAR-P12/CONT

CAR-P3/CAR-P12

5-HT1a

3.3

ND

2.4

GABAAα2

2.0

ND

2.0

5-HT1d

1.9

ND

2.1

GABAAα4

1.8

ND

2.0

5-HT1e

1.6

ND

1.6

GABAAα5

1.9

1.4

1.4

5-HT1f

1.8

ND

2.0

GABAAα6

2.9

1.7

1.7

5-HT2c

1.4

ND

1.7

GABAB1b

2.6

ND

2.4

5-HT4

1.9

ND

2.4

GABAB1c

2.2

1.5

1.5

5-HT5a

3.0

ND

2.3

NR1-1b

3.2

2.4

1.3

5-HT5b

3.1

2.1

1.5

NR1-4a

2.2

ND

2.0

5-HT6

1.7

ND

1.7

NR2A

2.1

1.5

1.4

IL-1α

1.6

ND

1.6

NR2D

2.3

1.5

1.5

IL-5

2.5

1.6

1.6

NR3B

1.6

ND

2.0

IL-6

1.8

ND

2.2

GluRD

2.0

ND

2.0

IL-12A

1.7

ND

1.3

GluR6

2.1

ND

1.7

IL-12R β1

6.1

ND

4.3

mGluR1a

2.5

1.4

1.8

IL-15

2.4

ND

2.0

CGRPR

2.6

1.5

2.4

IL-20

3.4

ND

2.4

NT-4

2.0

1.2

1.6

IL-24

3.5

ND

3.0

CALK2

2.5

ND

1.9

TrkA

2.3

ND

2.0

VGF

2.6

ND

1.4

TrkC

1.5

ND

1.4

NK2

1.5

2.2

0.7