Table 1 Acid dependent effects on the activation rate of capsaicin-activated responses. Increasing the acidity of the external solution during a 1 second pre-pulse resulted in an increase in the activation rate of capsaicin-evoked currents in rat TRPV1 expressing HEK-293 cells. Values are the mean ± SEM of the calculated activation rate (τ) using a single exponential fit.
From: Acidification of rat TRPV1 alters the kinetics of capsaicin responses
Condition | τ (ms) | n |
|---|---|---|
Control (pH 7.4) | 1176 ± 195 | 15 |
pH 6.8 | 1021 ± 128 | 15 |
pH 6.0 | 632.0 ± 86.5 | 13 |
pH 5.0 | 242.7 ± 49.7 | 7 |