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Table 2 Comparison of the activation and deactivation kinetics of TRPV1. Mean activation and deactivation rates of responses from TRPV1 expressing HEK-293 cells following application of capsaicin (1 μM), acidic pH (5.5) or the combination. Row 3 represents activation and deactivation rates of currents evoked by 1 μM capsaicin following pre-exposure to acidic conditions (pH 5.5). Row 4 represents the activation rates of acid-evoked currents following pre-exposure to capsaicin (1 μM). The absolute value of rate measurements had slight day-to-day variations (possibly due to relative position of the drug application tube). Therefore values in this table are from cells in which direct comparisons can be made. Values are mean ± S.E.M.

From: Acidification of rat TRPV1 alters the kinetics of capsaicin responses

  Activation Rates Deactivation Rates
  τ (ms) n τ (ms) n
1 μM Capsaicin 847 ± 119 4 845 ± 60 4
pH 5.5 917 ± 307 3 56 ± 13 4
1 μM CAP (pH 5.5) 149.3 ± 17 4 10553 ± 1880 4
pH 5.5 (1 μM CAP) 93 ± 13 3 -not tested-  
  1. Note: Rates from experiments shown in Figures 4 and 5.